R&D Service
From drug discovery to commercialization of the "one-stop" service platform
New Drug Preclinical Research Service
Caremo conducts preclinical pharmacokinetic (PK) studies encompassing in vitro and in vivo investigations of:
- Small-molecule compounds
- Peptide-based therapeutics
- Biologics
Key assessments include:
- Plasma pharmacokinetic profiling
- Tissue distribution studies
- Excretion pathway characterization
- Mass balance studies
· Plasma protein binding test
· Plasma stability test
· Drug&drug interaction
· Transmembrane transport test
· Hepatocyte metabolic test
· CYP450 enzyme inhibition test
· CYP450 enzyme induction test
· Metabolic phenotype study
· Metabolic pathway confirmation
· Metabolite speculation
· Hepatocyte metabolic stability test
· Metabolite confirmation
· Haemodynamics study
· Tissue distribution study
· Blood brain barrier
· Excretion study
· Material balance
Service Advantages
High level team formed by the core of well-known pharmacology and pharmacodynamics experts
Caremo has built a rigorous and excellent research team，the core members are composed of experienced biology expert, returnee pharmacologist and professionals with doctoral backgrounds from well-known universities. Also, our core technicians are from eminent companies with professional laboratory management experience.
FTE and FFS, two efficient business models in parallel
The customized projects can be completed quickly with high success rate, and the project teams are very experienced, we can effectively meet the different needs of companies at different stages for compound synthesis.
Comprehensive and advanced equipment and data management system
We have a 11000+㎡ research center, including 2500㎡ new drug preclinical research laboratory (including P2 lab), fully equipped with advanced equipment and digital data management system, and we have CNAS quality management system, and introducing advanced GLP management concept. The experimental operations are strictly complied with ICH and NMPA guidelines to ensure the efficient operation of the whole process of the laboratory, and able to conduct multiple animal experiments at the same time and ensure the integrity and accuracy of experiments data.
PROTAC target protein degradation test
Caremo can detect the target of PROTAC drugs. PROTAC action mechanism is distinguished from traditional drugs which are relied on binding of molecules and target proteins. PROTAC mainly depends on the proximity of E3 ligase and target protein, thereby to degrade the target protein, The drug is evaluated through the detection of cell level and protein level.
Follow us
Contract Us：
Add：Building C6, No. 9, Weidi Road, Qixia District, Nanjing
P.C：210046
Tel：025-85760569
M.P：bd@caremo.com.cn
